Botox®, Xeomin®, and Letybo® each last about 3–4 months, depending on the area treated, dosage, and patient metabolism. Some individuals report longer effects with Letybo, while others prefer the purified formulation of Xeomin or the predictable profile of Botox. These injectable wrinkle treatments all relax facial muscles, but differences in formulation and onset speed influence how long they work and how they feel.
At For A New You Medspa in Holliston, we help patients choose the right neuromodulator for their features, lifestyle, and desired outcomes. Duration is only one factor; choosing the right product also depends on how your face moves, how quickly you metabolize treatments, and what kind of expression you want to maintain.
Quick Comparison Table: Duration, Onset, Unique Traits
| Product | Typical Duration | Onset Time | Unique Attribute |
| Botox® | 3–4 months | 3–5 days | Trusted, precise targeting |
| Xeomin® | 3–4 months | 3–4 days | Pure, no accessory proteins |
| Letybo® | 3–4 months* | 2–3 days | Fast onset, high purity finish |
Some patients report longer-lasting results (up to 6 months) with Letybo, though more clinical studies are ongoing.
This quick reference shows that while all three options offer similar treatment timelines, each one performs differently in terms of onset and formulation. The next sections explain these differences in more detail.
What Are Neuromodulators?
Neuromodulators are injectable treatments that relax targeted facial muscles to reduce the appearance of dynamic wrinkles. These include forehead lines, crow’s feet, glabellar lines (“11s”), and bunny lines across the bridge of the nose.
The active ingredient in all three, Botox, Xeomin, and Letybo, is botulinum toxin type A. This ingredient blocks signals between nerves and muscles, which prevents repeated movement in treated areas. As muscles stay relaxed, expression lines soften, and skin appears smoother.
Neuromodulators are one of the most customizable and low-downtime options for facial rejuvenation. A skilled injector can use small amounts in specific zones to help you maintain natural movement while smoothing deep lines.
Botox®: The Original Gold Standard
Botox typically lasts 3–4 months in most treatment areas. Results begin to appear in 3 to 5 days, with full smoothing effects seen within two weeks. Botox has a medium diffusion profile, which allows for precise yet even muscle softening.
This product has been FDA approved for cosmetic use since 2002. It remains a first-choice option for patients who want reliable, well-studied results across common zones like the forehead, glabella, and crow’s feet.
Botox includes complex proteins in its formulation, which can help deliver the active ingredient to targeted muscles. Some patients respond better to Botox’s formulation, especially when treated consistently over time.
Xeomin®: The Pure Form Alternative
Xeomin lasts about 3–4 months and starts working in 3 to 4 days. It is formulated without accessory proteins, making it a “naked” neurotoxin that may reduce the risk of developing antibody resistance.
This clean formulation can benefit patients who feel they’ve stopped responding to other wrinkle relaxers. Xeomin’s low diffusion makes it ideal for treating smaller zones or refining areas that require precision, such as frown lines or brow lifts.
Patients often describe Xeomin as feeling lighter post-treatment. While results mirror Botox in duration and effect, some individuals choose Xeomin specifically for its purity and reduced protein load.
Letybo®: The Fast Onset Newcomer
Letybo typically lasts 3–4 months and begins working within 2–3 days. Some patients report visible results within 48 hours, making it one of the fastest-acting wrinkle relaxers available in the U.S. market.
Approved by the FDA in 2023, Letybo has been widely used in Korea and other international aesthetic markets. Its high-purity formulation offers smooth diffusion, ideal for areas that require subtle muscle movement like crow’s feet and the forehead. Some patients notice effects lasting closer to 5–6 months, although more long-term U.S. clinical data are still emerging.
Letybo appeals to individuals who value natural expression and want results to appear quickly without looking frozen. Its rapid onset and soft finish make it a strong choice for active individuals or those planning events.
Factors That Affect Duration (Beyond the Product Itself)
The longevity of a wrinkle relaxer depends on more than the product itself. Several individual factors affect how long results last after injection:
- Metabolism: Faster metabolisms can break down botulinum toxin more quickly.
- Muscle strength: Larger or more expressive muscles (like the frontalis) often require higher doses and may wear off sooner.
- Injection technique: Placement, depth, and precision directly impact how the product performs.
- Dose and dilution: Underdosing can reduce duration; overdilution may spread the product beyond the target zone.
- Product tolerance: Patients who’ve used a neurotoxin frequently may develop antibodies; additive-free options like Xeomin can help in those cases.
At For A New You Medspa in Holliston, every injection plan is adjusted to your facial anatomy, muscle strength, and goals, ensuring optimal product performance over time.
Area Specific Longevity (Forehead vs 11s vs Crow’s Feet)
Forehead injections tend to last longer than crow’s feet due to lower muscle activity in that region. The glabellar complex (between the brows) also responds well to most wrinkle relaxers and holds results for 3–4 months.
| Area | Typical Duration |
| Forehead Lines | 3–4 months |
| Glabellar Lines | 3–4 months |
| Crow’s Feet | 2.5–3.5 months |
Muscles around the eyes are thinner and more active, which can cause products to wear off slightly faster. For high movement zones like crow’s feet, Letybo may offer more flexibility and a faster response.
When Should You Schedule Your Next Injection?
Most patients benefit from retreatment every 3 to 4 months. Scheduling before full movement returns helps maintain a consistently refreshed appearance and prevents the reformation of deep lines.
Your retreatment schedule should reflect how your muscles recover, how expressive your face is, and how your last treatment performed. At our practice, we track your response over time and adjust your plan for optimal long-term results.
Repeat treatments also help “train” muscles to remain more relaxed, meaning many patients notice their results lasting slightly longer with consistent care.
Which One Lasts the Longest? (Final Verdict)
All three neuromodulators, Botox, Xeomin, and Letybo, last about 3–4 months in most patients. Letybo may last longer for some individuals, but performance varies based on anatomy and injection technique.
| Product | Duration Summary | Best For |
| Botox® | Consistent 3–4 months | Predictable zones like the glabella or the forehead |
| Xeomin® | Similar 3–4 months | Patients seeking pure formulation or low resistance risk |
| Letybo® | 3–4 months (up to 6) | Fast onset and soft, natural expression |
Choosing the longest-lasting option isn’t always the same as choosing the best. The right match depends on your goals, facial structure, and lifestyle.
Want Longer Lasting Results from Your Wrinkle Relaxer?
If you’re exploring wrinkle relaxers and want results that match your facial anatomy and lifestyle, we’re here to help. At For A New You Medspa in Holliston, every neuromodulator treatment is guided by precision, experience, and a commitment to natural-looking results.
Schedule your consultation to learn which product will help you maintain smoother skin longer, with or without the frozen look.
Frequently Asked Questions
How long do Botox, Xeomin, and Letybo typically last?
Botox, Xeomin, and Letybo usually last 3 to 4 months. Some patients may see Letybo effects last up to 6 months, depending on metabolism, treatment area, and individual muscle activity.
Does Letybo last longer than Botox?
Letybo may last slightly longer than Botox for some individuals. Factors such as muscle movement, treatment location, and how your body metabolizes the product can influence how long results are maintained.
Can I switch between Botox, Xeomin, and Letybo?
Yes, switching between neurotoxins is common. Many patients alternate between Botox, Xeomin, and Letybo to optimize results or minimize the potential risk of developing resistance over time.
Do crow’s feet fade faster than forehead lines?
Yes, crow’s feet often fade faster. The muscles around the eyes are more active, which causes the product to break down more quickly compared to areas like the forehead with less constant movement.
When should I book my next appointment?
Book your follow-up every 3 to 4 months to maintain smooth results. Scheduling before full muscle movement returns helps prevent wrinkles from re-forming and keeps your treatment consistent.